Cell deformability-based microfluidic platform for cell sorting and cell phenotypic mapping (XY Liu et al, PNAS, 2026).
eLuminator consist of a microstructured conductive layer, an electroluminescent layer, and a transparent electrode layer. The eLuminator is capable of pressure visualization for surgical training (ZX Wu et al, Nature Communications, 2026).
2025 President’s Science Award winners – Prof Lim Chwee Teck, Prof Lisa Ng (03 Oct 2025).
iStretch - Strain dependent thermochromic changes during thermotherapy applications. Due to the generation of heat and the correlation among the strain, color, and temperature, iStretch can be attached to different body joints for thermotherapy, visual strain sensing, and overheat warnings (SC Fan et al, Advanced Science, 2025).
Tunable flow Gut Microbiome on a Chip tfGMoC inspired by mechanically active dynamics of intestinal. By controlling the thickness of the bottom PDMS layer (≈400 µm), a pneumatically deflectable quake valve was created to facilitate cyclic compression and expansion of the ceiling of the cell-culture chamber by pumping or withdrawing air into the air chamber (JY Lee et al, Small, 2025).
Establishment of the dynamic probiotic-enriched µGut (LGG-µGut). LGG colonized on the µGut in various forms, covering from the crypt to the villus (JY Lee et al, Advanced Science, 2024).
HaptGlove - An archery game designed to allow users to feel the string tension when shooting arrows. Users first feel their index, middle and ring fingers touch the string. Then, they feel the increasing tension when they flex fingers while pulling the string. After aiming at the target, a small finger extension fires the arrow, removing applied haptics simultaneously. (JM Qi et al, Advanced Science, 2023).
HaptGlove - The actuation frequency of the haptic module for the index finger was controlled at 30 Hz to mimic the sensation when touching a vibrating motor. Movie demonstrates the sensing of heartbeat, raindrops and engine vibration. (JM Qi et al, Advanced Science, 2023).
Deformation of a non rupturing cancer cell line MCF7. (J Kuan et al, Advanced Science, 2023).
A microfluidic deformation assay that can perform mechanical selection on 30,000 suspended cancer cells per minute. (J Kuan et al, Advanced Science, 2023).
Stretchable multilayered displays with bilayer liquid-solid conductor (b-LSC) circuits, VIAs, and SMDs. (SW Chen et al, Advanced Materials, 2023).
Collective live-cell extrusions are incurred under long-term apical-to-basal (AtB) field application. Epifluorescence imaging of an H1–GFP MDCK monolayer shows the evolution of nucleus/cellular distributions over days during AtB-field application. Bright patches are collective live-cell extrusions. Scale bar, 50 μm. (TB Saw et al, Nature Physics, 2022).
MDCK cells overexpressing Snail transcription factor migrating into a 25 μm diameter microtube (X Wang et al, Nature Communications 2017).
MDCK α-catenin KD cells collectively migrating into a microtube of 100 μm in diameter (X Wang et al, Nature Communications 2017).
Direction of the velocity fields in H1-GFP MDCK TCS migrating in a microtube of 250 μm in diameter. Each frame is 10 minutes apart and video is played at 10 frames per second (X Wang et al, Nature Communications 2017).
MDCK H1-GFP cells collectively migrating into a 100 μm diameter microtube. Scale bar 100 μm (X Wang et al, Nature Communications 2017).
Direction of the velocity fields in H1-GFP MDCK TCS migrating in a microtube of 25 μm in diameter. Each frame is 10 minutes apart and video is played at 10 frames per second (X Wang et al, Nature Communications 2017).
A 3D movie showing MDCK H1-GFP cells collectively migrating into a 100 μm diameter microtube (X Wang et al, Nature Communications 2017).
Direction of the velocity fields in H1-GFP MDCK TCS migrating in a microtube of 100 μm in diameter. Each frame is 10 minutes apart and video is played at 10 frames per second (X Wang et al, Nature Communications 2017).
MDCK E-cadherin-GFP cells collectively migrating into microtubes of 25 and 100 μm in diameter. Scale bars 20 μm (X Wang et al, Nature Communications 2017).
AFM imaging of malaria infected cells.
Malaria infected red blood cells adhering and rolling on ICAM-1 coated surface.
Micropipette aspiration of a malaria infected red blood cell.
Dual pipette assay of cell-cell adhesion of malaria infected red blood cells.
Squeezing of a breast cancer cell (MCF-7 with stained nucleus) into a microfluidic channel (10x10um).
Collective migration of epithelial cells (Nuclei labeled with DAPI).
MDCK cells are unable to close a 100 μm diameter non-adhesive gap. Scale bar 50 μm. (SRK Vedula et al, Nature Comm, 2015).
a-catenin knockdown HaCaT cells are unable to close a 100 μm diameter non-adhesive gap. Scale bar 50 μm. (SRK Vedula et al, Nature Comm, 2015).
HaCaT cells closing a 100 μm diameter non-adhesive gap. Scale bar 50 μm. (SRK Vedula et al, Nature Comm, 2015).
HaCaT cells partially closing a 150 μm diameter non-adhesive gap. Scale bar 50 μm. (SRK Vedula et al, Nature Comm, 2015).
HaCaT cells unable to close a 200 μm diameter non-adhesive gap. Scale bar 50 μm. (SRK Vedula et al, Nature Comm, 2015).
MDCK epithelial cells do not form well-developed epithelial bridges but some ‘nascent’ bridge-like structures can be observed at the junction of the fibronectin strip and the reservoir. Scale bar 50 μm, Time stamp (hours: minutes). (SRK Vedula et al, Nature Materials, 2014).
Keratinocytes migrating from the reservoir (RES) into the 10 μm wide fibronectin strips form multicellular suspended epithelial bridges over the non-adhesive regions between the fibronectin strips. Scale bar 50 μm, Time stamp (hours: minutes). (SRK Vedula et al, Nature Materials, 2014).
Migration of HaCaT cells on 10 μm micropatterns in the presence of 50 μM blebbistatin. Despite cells migrating into the fibronectin strips, epithelial-bridge formation was markedly inhibited, suggesting that myosin contractility was indeed required for the formation of epithelial bridges. Scale bar 50 μm, Time stamp (hours: minutes). (SRK Vedula et al, Nature Materials, 2014).
Epithelial bridges collapse completely in presence of calyculin A 20 nM. Rupture starts at concave leading front. Scale bar 50 μm, Time stamp (minutes). (SRK Vedula et al, Nature Materials, 2014).
Laser ablation of the leading-cell front on the fibronectin strip results in immediate elastic recoil of the epithelial bridge, confirming their predominantly elastic nature as well as the existence of tension within them. (SRK Vedula et al, Nature Materials, 2014).
Radial flow of actin filaments on soft substrate. A REF52 cell, transiently expressing RFP-ftractin (labels F-actin), adhered to a soft substrate (9 nN/μm). (M Gupta et al, Nature Comm, 2015).
MCF-10A cells (benign breast cancer cells) migrating on 200 μm fibronectin patterns. Cells closer to the edge of the pattern show a collective behavior but those in the centre migrate randomly. Time stamp shows hours: minutes. (K Doxzen et al, Integrative Biology, 2013).
MCF-7 cells (invasive breast cancer cells) migrating on 200 μm fibronectin patterns showing little tendency for collective behavior. Time stamp shows hours: minutes. (K Doxzen et al, Integrative Biology, 2013).
MDA-MB-231 cells (invasive breast cancer cells) migrating on 200 μm fibronectin patterns showing little tendency for collective behavior. Time stamp shows hours: minutes.(K Doxzen et al, Integrative Biology, 2013).
Confluent MDCK cells exhibiting synchronized rotation on a 200 μm diameter fibronectin pattern. Time stamp shows hours: minutes. (K Doxzen et al, Integrative Biology, 2013).
MDCK cells migrating on a 500 μm diameter fibronectin pattern showing a localized ‘vortex’ ~ 300 μm in diameter. Time stamp shows hours: minutes. (K Doxzen et al, Integrative Biology, 2013).
Margination of late stage infected red blood cells.
Deformability based cell margination: Separation of late stage infected red blood cells (HW Hou et al, Lab-on-a-Chip, 2010).
Shear modulated inertial microfluidic biochip: High throughput separation of circulating tumor cells (AAS Bhagat et al, Lab-on-a-Chip, 2011).
High speed video (6400 fps) illustrating the complete isolation of MDA-MB-231cells from WBCs at the device outlet. Focused MDA-MB-231 cells (near the inner wall (top side)) are clearly distinguished from WBCs based on morphology and phase contrast. Few platelets are observed going into the CTC outlet. However, their presence do not interfere during counting using immunofluorescence staining or downstream molecular assay such as PCR. (ME Warkiani et al, Lab on a Chip, 2014).
High speed video (6400 fps) captured at the outlet of spiral biochip showing isolation of few CTCs from peripheral blood of a patient with advanced metastatic lung cancer. This movie clearly demonstrates the performance of our device for efficient enrichment of CTC from blood samples. (ME Warkiani et al, Lab on a Chip, 2014).
High speed video (6400 fps) captured at the outlet of spiral biochip showing isolation of few CTCs from peripheral blood of a patient with advanced metastatic lung cancer. This movie clearly demonstrates the performance of our device for efficient enrichment of CTC from blood samples. (ME Warkiani et al, Analyst, 2014).
CTChip detection & isolation of circulating tumor cells (SJ Tan et al, Biomed Microdev, 2009; SJ Tan et al, Biosensors & Bioelect, 2010).
Stretchability and Flexibility of the STEP microfiber (LT Yu et al, ACS Applied Materials & Interfaces, 2018).
The STEP microfiber as a strain gauge on the bandage (LT Yu et al, ACS Applied Materials & Interfaces, 2018).
Washability of the STEP microfiber (LT Yu et al, ACS Applied Materials & Interfaces, 2018).
Pulse monitoring using the STEP microfiber sewn in a glove (LT Yu et al, ACS Applied Materials & Interfaces, 2018).
NUS researchers develop smart bandage for onsite chronic wound monitoring (21 October 2021).
NUS PhD eOpen Day 2020 - Engineering the Future of Medicine (Presented by Prof Lim Chwee Teck) (29 October 2020).
Prof Lim Chwee Teck is a Falling Walls Finalist at the Falling Walls and Berlin Science Week: World Science Summit 2020 (19 October 2020).
CNA938 Tech Talk - New Immersive Gaming Experience (2 October 2020).
NUS researchers develop new smart gaming glove - 8 World (20 August 2020).
NUS researchers develop new smart gaming glove - NUS (20 August 2020).
COVID-19: NUS researchers develop portable system that produces swab test results in an hour (1 July 2020).
Microfluidics for Disease Diagnosis & Precision Therapy: From Bench to Bedside (22 June 2020).
Reimagining Medicine: Detecting Cancer with a Chip (29 May 2020).
Money FM 89.3 Health Suites: Liquid Biopsies - A Less Invasive Way to Treat Cancers (11 Mar 2020).
City of Innovation: Singapore – Diabetic Insoles (09 Dec 2019).
Advancing Health through Innovation: Perspectives from an Entrepreneurial Scientist, SGInnovate (03 Oct 2019).
Wearable sensor, Channel 5 News (15 Nov 2017).
Wearable sensor, Channel 8 News (15 Nov 2017).
Wearable sensor, Channel News Asia (15 Nov 2017).
Invented in Singapore : A Dynamic Education, Channel News Asia (19 Feb 2016).
Prof. Lim Chwee Teck on Microfluidics and Cancer (MBI).
Report on Liquid based Tactile Sensor, Channel News Asia (23 Sept 2015).
Prof. Lim Chwee Teck talks about his scientific research, Joint IFOM-MBI Conference (July 2014).
The Start-UP: ClearBridge BioMedics, Channel News Asia (24 Dec 2013).
Why Engineering?, FoE, NUS (13 Sept 2013).
Report on Clearbridge BioMedics, Channel News Asia (13 Mar 2013).
Growing big ideas, Channel NewsAsia (08 Sept 2011).
New Frontiers, Episode 3, Channel i (28 April 2004).